May 2021

Perimeter Institute for Theoretical Physics

In his Perimeter Public Lecture webcast on May 5, 2021, Harvard professor L. Mahadevan will take viewers on a journey into the mathematical, physical, and biological workings of morphogenesis to demonstrate how researchers are beginning to unlock secrets that have vexed scientists since Darwin.

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Related Publications

On the growth and form of the gut T. Savin, N.A. Kurpios, A.E. Shyer, P. Florescu, H. Liang, L. Mahadevan & C.J. Tabin,  Nature  476:57-62, 2011. [View PDF] [Download PDF]
Tissue Tectonics: morphogenetic strain rates, cell shape change and intercalation G. Blanchard, A. Kabla, L. Butler, B. Sanson, N. Gorfinkiel, L. Mahadevan and R. Adams,  Nature Methods , 6(6), 458-64, 2009. [View PDF] [Download PDF]
Morphogenesis one century after On Growth and Form  Thomas Lecuit and L. Mahadevan,  Development  144, 4197-4198, 2017. [View PDF] [Download PDF]
BMP signaling controls buckling forces to modulate looping morphogenesis of the gut N. L. Nerurkar, L. Mahadevan, and C.J. Tabin,  Proceedings of the National Academy of Sciences  (USA), 114, 2277-82, 2017. [View PDF] [Download PDF]
Villification: how the gut gets its villi A. Shyer, T. Tallinen, N. Nerurkar, Z. Wei, E. Kim, D. Kaplan, C. Tabin and L. Mahadevan  Science,  342, 212-218, 2013. [View PDF] [Download PDF]
A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia S.J. England, G.B. Blanchard, L. Mahadevan, and R.J. Adams,  Development , 133, 4613, 2006. [View PDF] [Download PDF]
Gyrification from constrained cortical expansion T. Tallinen, J.Y. Chung, J.S. Biggins, and L. Mahadevan,  Proceedings of the National Academy of Sciences (USA) , 111, 35:12667-12672, 2014. [View PDF] [Download PDF]
On the growth and form of cortical convolutions T. Tallinen, J.Y. Chung, F. Rousseau, N. Girard, J. Lefèvre, and L. Mahadevan,  Nature Physics , 12, 588-93, 2016. [DOI] [View PDF] [Download PDF]
Surface sulci in squeezed soft solids T. Tallinen, J.S. Biggins, and L. Mahadevan,  Physical Review Letters , 110, 024302, 2013. [View PDF] [Download PDF]
Scale and nature of sulcification patterns E. Hohlfeld and L. Mahadevan,  Physical Review Letters , 109, 025701, 2012. [View PDF] [Download PDF]
Unfolding the sulcus E. Hohlfeld and L. Mahadevan,  Physical Review Letters , 106, 105702, 2011. [View PDF] [Download PDF]
On the growth and form of shoots R. Chelakkot and L. Mahadevan,  Journal of the Royal Society Interface , 14, 20170001, 2017. [View PDF] [Download PDF]
Spatio-temporal integration in plant tropisms
Y. Meroz, R. Bastien and L. Mahadevan Interface 16, 20190038, 2019. [DOI] [View PDF] [Download PDF]
Excitable dynamics and yap-dependent mechanical cues drive the segmentation clock A. Hubaud, I. Regev, L. Mahadevan, O. Pourquié,  Cell  171, 1-15, 2017. [View PDF] [Download PDF]
Mechanical coupling coordinates the co-elongation of axial and paraxial tissues in avian embryos F. Xiong, W. Ma, B. Benazaref, L. Mahadevan, O. Pourquie, BioRxiv [ONLINE ARTICLE] [DOI]
Size control of the inner ear via hydraulic feedback. K.R. Mosaliganti, I. A. Swinburne, C.U. Chan, N.D. Obholzer, A. A. Green, S. Tanksale, L Mahadevan, and S.G. Megason, eLife 2019;8:e39596. 2019. [DOI] [View PDF] [Download PDF]
Hydraulic control of mammalian embryo size and cell fate
C.J. Chan, M. Costanzo, T. Ruiz-Herrero, G. Monke, R. Petrie, L. Mahadevan, T. Hiiragi, Nature 571, 112–116, 2019. [DOI] [View PDF] [Download PDF]
Muscular hydraulics drive larva-polyp morphogenesis. Anniek Stokkermans, Aditi Chakrabarti,Kaushikaram Subramanian, Ling Wang, Sifan Yin, Prachiti Moghe, Petrus Steenbergen, Gregor Mönke, Takashi Hiiragi, Robert Prevedel, L. Mahadevan Aissam lkmi. Current Biology. Volume 32, Issue 21, September 16, 2022 . [ONLINE ARTICLE] [DOI] [View PDF] [Download PDF]
Organ size control via hydraulically gated oscillations Teresa Ruiz-Herrero, Kévin Alessandri, Basile V. Gurchenkov, Pierre Nassoy and L. Mahadevan,  Development  144, 4422-4427, 2017. [View PDF] [Download PDF]