Excitable dynamics and yap-dependent mechanical cues drive the segmentation clock
Excitable dynamics and yap-dependent mechanical cues drive the segmentation clock
A. Hubaud, I. Regev, L. Mahadevan, O. Pourquié, Cell 171, 1-15, 2017.
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Abstract
In vitro system supporting stable segmentation clock
oscillations
d A cell-density effect controls the onset of oscillations in vitro
d Yap-dependent mechanical signal acts as a control
parameter for oscillations
d Segmentation clock has properties of an excitable system