FoldedBrain

Replicating folding of a fetal human brain

Feb 2016

The distinctive troughs and crests of the human brain are actually not present in most animal brains; highly folded brains are seen only in a handful of species, including some primates, dolphins, elephants and pigs. In humans, folding begins in fetal brains around the 20th week of gestation and is completed only when the child is about a year and a half.

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Gyrification from constrained cortical expansion T. Tallinen, J.Y. Chung, J.S. Biggins, and L. Mahadevan,  Proceedings of the National Academy of Sciences (USA) , 111, 35:12667-12672, 2014. [View PDF] [Download PDF]
Surface sulci in squeezed soft solids T. Tallinen, J.S. Biggins, and L. Mahadevan,  Physical Review Letters , 110, 024302, 2013. [View PDF] [Download PDF]
Scale and nature of sulcification patterns E. Hohlfeld and L. Mahadevan,  Physical Review Letters , 109, 025701, 2012. [View PDF] [Download PDF]
Unfolding the sulcus E. Hohlfeld and L. Mahadevan,  Physical Review Letters , 106, 105702, 2011. [View PDF] [Download PDF]