A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia

A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia

A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia S.J. England, G.B. Blanchard, L. Mahadevan, and R.J. Adams,  Development , 133, 4613, 2006.
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Abstract

Mechanisms for shaping and folding sheets of cells during development are poorly understood. An example is the complex
reorganisation of the forebrain neural plate during neurulation, which must fold a sheet into a tube while evaginating two eyes
from a single contiguous domain within the neural plate. We, for the first time, track these cell rearrangements to show that
forebrain morphogenesis differs significantly from prior hypotheses. We postulate a new model for forebrain neurulation and
demonstrate how mutations affecting two signalling pathways can generate cyclopic phenotypes by disrupting normal cell
movements or introducing new erroneous behaviours.