Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces

Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces

Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces A. Levin, T. C. T. Michaels, T. O. Mason, T. Müller, L. Adler-Abramovich, L. Mahadevan, M. E. Cates, E. Gazit, and T. P. J. Knowles  ACS Appl. Mater. Interfaces , 10, 27578−27583. 2018.
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Abstract

The release of nanoscale structures from
microcapsules, triggered by changes in the capsule in response
to external stimuli, has significant potential for active
component delivery. Here, we describe an orthogonal strategy
for controlling molecular species’ release across oil/water
interfaces by modulating their intrinsic self-assembly state. We
show that although the soluble peptide Boc-FF can be stably
encapsulated for days, its self-assembly into nanostructures
triggers jet-like release within seconds. Moreover, we exploit this self-assembly-mediated release to deliver other molecular
species that are transported as cargo. These results demonstrate the role of self-assembly in modulating the transport of peptides
across interfaces.