Many problems in science and engineering are inverse problems. In science, an experimental result that requires an explanation asks the question – given the data, what is the theory/model that provides it? In engineering, a given function (in a product/software …. ) requires a design that provides the function. In cognitive neuroscience, one asks how one can detect, classify and recognize the distal origin of signals from their proximal sensory cues, converting well known forward problems in the physical sciences and engineering, e.g. optics, hydrodynamics and acoustics to inverse problems in psychophysics associated with vision, olfaction, and audition.
Inverse problems are often defined by a goal to be achieved subject to some constraints (such as adherence to physical law, robustness to noise, symmetry), and are usually not well-posed, i.e. they can lead to multiple answers. Our interests in this area span both methodological and practical aspects. In methodology, a recent interest is in statistical-geometric inverse problems from perceptual psychology and cognition. And from a practical perspective, we have worked on a diverse range of applications that include structural optimization, strategies for 3d and 4d printing, optimal drug treatment protocols for protein misfolding diseases, efficient locomotion etc.
Biomimetic 4D printing
A. S. Gladman, E. A. Matsumoto, R.G. Nuzzo,
L. Mahadevan, and J.A. Lewis, Nature Materials , 1
5, 413-19, 2016.
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Shape-shifting structured lattices via multimaterial 4D printing.
J.W. Boley, W.M. van Rees, C. Lissandrello, M.N. Horenstein, R.L. Truby, A. Kotikian, J.A. Lewis, and
L. Mahadevan,
Proc. Natl. Acad. Sci.,
116 (42) 20856-20862, 2019.
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Programming shape using kirigami tessellations
G. P. T. Choi, L. H. Dudte and
L. Mahadevan,
Nature Materials 18, 999–1004. 2019.
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Programming curvature using origami tessellations
L.H. Dudte, E. Vouga, T. Tachi and
L. Mahadevan, Nature Materials ,
15, 583-88, 2016.
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The branch with the furthest reach
Z. Wei, S. Mandre and
L. Mahadevan, Europhysics Letters ,
97, 14005, 2012.
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Forward and inverse problems in the mechanics of soft filaments
M. Gazzola, L. H. Dudte, A. G. McCormick and
L. Mahadevan, Royal Society Open Science
5: 171628, 2018.
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Controlled growth and form of precipitating microsculptures
C. N. Kaplan, W. L. Noorduin, L. Li, R. Sadza, L. Folkertsma, J. Aizenberg,
L. Mahadevan, Science
355, 1395-99, 2017.
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Optimal control of plates using incompatible strains
G.W. Jones and
L. Mahadevan, Nonlinearity
28, 3153–3174, 2015.
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Optimal intercellular competition in senescence and cancer. Thomas C. T. Michaels and
L. Mahadevan, Royal Society. Volume 479, Issu 2276, 30 August 2023.
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Optimal policies for mitigating pandemic costs: a tutorial model. M Serra, S al-Mosleh, S Ganga Prasath, V Raju, S Mantena, J Chandra, S Iams
L. MAHADEVAN Physical Biology. Volume 19, 9 August 2022 .
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Optimal strategies for inhibition of protein aggregation
T.C. Michaels, C. Weber and
L. Mahadevan, PNAS
116 (29) 14593-14598, 2019.
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Optimal strategies for throwing accurately
M. Venkadesan and
L. Mahadevan, Royal Society Open Science ,
4: 170136. 2017.
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Optimal switching between geocentric and egocentric strategies in navigation
O. Peleg and
L. Mahadevan Royal Society Open Science
3: 160128, 2016.
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Optimal transport and control of active drops. Suraj Shankar, Vidya Raju and
L. Mahadevan,
Proceedings of the National Academy of Sciences. ,119 (35), e2121985119, August 24, 2022
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Optimal vein density in artificial and real leaves
X. Noblin,
L. Mahadevan, I. Coomaraswamy, D. Weitz, N. Holbrook and M. Zwieniecki, Proceedings of the National Academy of Sciences (USA),
105, 9140, 2008.
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Balancing on tightropes and slacklines
P. Paoletti and
L. Mahadevan, Journal of the Royal Society - Interface ,
9, 2097-2108, 2012.
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Feedback control of protein aggregation.
A. J. Dear, T.C. T. Michaels, T. P. J. Knowles, and
L. Mahadevan,
J. Chem. Phys. 155, 064102 (2021)
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Balancing efficiency and homogeneity of biomaterial transport in networks. S. Liese,
L. Mahadevan and A. Carlson.
Europhysics Letters, Vol. 135 | No. 5
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Planar controlled gliding, tumbling and descent.P. Paoletti and
L. Mahadevan, Journal of Fluid Mechanics,
698, 489-516, 2011.
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Controlled gliding and perching through deep-reinforcement-learning.
G.Novati,
L. Mahadevan, and P. Koumoutsakos,
Physical Review Fluids 4, 093902, 2019.
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Coordinated crawling via reinforcement learning.
S. Mishra, W. van Rees,
L. Mahadevan,
Royal Society-Interface, 17: 20200198, 2020.
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Intermittent locomotion as an optimal control strategy
P. Paoletti and
L. Mahadevan, Proceedings of the Royal Society (A) ,
470, 20130535, 2014.
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Organ size control via hydraulically gated oscillations
Teresa Ruiz-Herrero, Kévin Alessandri, Basile V. Gurchenkov, Pierre Nassoy and
L. Mahadevan, Development
144, 4422-4427, 2017.
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